Question

Which of the following statements is incorrect regarding Samter’s triad?

• A. It is only triggered by aspirin
• B. Other NSAIDs with COX-1 blocking ability can also trigger symptoms.
• C. It is characterized by asthma, nasal polyps, and aspirin sensitivity.
• D. It involves overproduction of leukotrienes.

Hint:

In Samter’s triad, COX-1 inhibitors like aspirin and NSAIDs can worsen symptoms. The overproduction of leukotrienes is a key feature of this disease.

Answer 1

The Correct Option is A

Samter’s triad, also known as aspirin-exacerbated respiratory disease (AERD), is a chronic medical condition characterized by three key elements: asthma, nasal polyps, and sensitivity to aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs). The following analysis evaluates each provided statement regarding Samter’s triad:

• The statement "It is only triggered by aspirin" is incorrect. Samter’s triad is not exclusively triggered by aspirin; other NSAIDs, specifically those with cyclooxygenase-1 (COX-1) inhibiting properties, can also precipitate symptoms. This includes ibuprofen and naproxen, among others.
• The statement "Other NSAIDs with COX-1 blocking ability can also trigger symptoms" is correct. The COX-1 enzyme inhibition leads to an overproduction of leukotrienes, which are potent inflammatory mediators leading to the exacerbation of respiratory symptoms characteristic of the condition.
• The statement "It is characterized by asthma, nasal polyps, and aspirin sensitivity" accurately describes the clinical triad of conditions in affected individuals.
• The statement "It involves overproduction of leukotrienes" is true. The pathophysiology of Samter’s triad involves increased leukotriene production due to the inhibition of the cyclooxygenase pathway, redirecting arachidonic acid metabolism to the lipoxygenase pathway.

In summary, the incorrect statement is "It is only triggered by aspirin," as the condition can be exacerbated by a range of NSAIDs, not just aspirin.