Question

Which of the following statements is incorrect regarding Samter’s triad?

• A. It is only triggered by aspirin
• B. Other NSAIDs with COX-1 blocking ability can also trigger symptoms.
• C. It is characterized by asthma, nasal polyps, and aspirin sensitivity.
• D. It involves overproduction of leukotrienes.

Hint:

In Samter’s triad, COX-1 inhibitors like aspirin and NSAIDs can worsen symptoms. The overproduction of leukotrienes is a key feature of this disease.

Answer 1

The Correct Option is A

Samter’s triad, also known as aspirin-exacerbated respiratory disease (AERD), is characterized by the combination of asthma, nasal polyps, and aspirin sensitivity. It is a condition where the use of aspirin or other NSAIDs with COX-1 inhibition can lead to exacerbations of symptoms. Leukotrienes, which are inflammatory mediators, are overproduced in response to COX-1 inhibition, contributing to airway inflammation and worsening asthma and nasal symptoms.
- Option (1) is incorrect because Samter’s triad is not only triggered by aspirin; other NSAIDs with COX-1 blocking activity can also trigger symptoms.
- Option (2) is correct because other NSAIDs that inhibit COX-1 (e.g., ibuprofen, naproxen) can also cause exacerbations. - Option (3) is correct as Samter’s triad involves asthma, nasal polyps, and aspirin sensitivity.
- Option (4) is correct since the condition is associated with increased production of leukotrienes.