Question

Irregular pitting of nails with subungual hyperkeratosis is seen in ___________.

• A. Lichen planus
• B. Psoriasis
• C. Atopic dermatitis
• D. Alopecia areata

Answer 1

The Correct Option is B

Irregular pitting of nails with subungual hyperkeratosis is primarily associated with Psoriasis. This condition is a chronic inflammatory skin disorder that affects approximately 2% of the population. In the context of dermatology, nail involvement is a common manifestation of Psoriasis and can be observed in up to 50% of patients with cutaneous psoriasis.

Irregular pitting refers to tiny depressions on the surface of the nails, and it occurs due to defective keratinization of the nail plate, a process commonly impaired in psoriasis. Additionally, subungual hyperkeratosis refers to the accumulation of keratinous material under the nail, typically resulting in lifting or separation of the nail plate.

In comparison, the other conditions mentioned have different typical nail manifestations:

Condition	Nail Manifestation
Lichen planus	Ridge formation, thinning, and splitting
Atopic dermatitis	No characteristic nail changes
Alopecia areata	Regular nail pitting (geometric pattern)

Thus, the correct answer is Psoriasis, which is known for causing irregular nail pitting and subungual hyperkeratosis, among other skin symptoms.