Question:
How is mature insulin different from pro-insulin secreted by pancreas in humans?
How is mature insulin different from pro-insulin secreted by pancreas in humans?
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Think of the C-peptide as a "clip" that is removed to make the hormone active.
Updated On: Mar 9, 2026
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Solution and Explanation
Step 1: Understanding the Concept:
Insulin is synthesized as a pro-hormone that requires processing.
Step 2: Detailed Explanation:
Pro-insulin contains three chains: A, B, and an extra C-peptide.
During maturation, the C-peptide is removed. Mature insulin consists only of A and B chains linked by disulfide bridges.
Step 3: Final Answer:
Absence of C-peptide makes it mature.
Insulin is synthesized as a pro-hormone that requires processing.
Step 2: Detailed Explanation:
Pro-insulin contains three chains: A, B, and an extra C-peptide.
During maturation, the C-peptide is removed. Mature insulin consists only of A and B chains linked by disulfide bridges.
Step 3: Final Answer:
Absence of C-peptide makes it mature.
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