Question:

During Citric Acid cycle, the various organic acid undergo decarboxylation. Which of the following organic acids of the above cycle have $4C$, $5C$ and $6C$ respectively?

Updated On: Apr 2, 2025
  • Pyruvic acid, Malic acid and $\alpha$-Ketoglutaric acid
  • Pyruvic acid, $\alpha$-Ketoglutaric acid and Citric acid
  • Oxaloacetic acid, Citric acid and Succinic acid
  • Succinic acid, $\alpha$-Ketoglutaric acid and citric acid
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The Correct Option is D

Solution and Explanation

The Citric Acid Cycle (Krebs cycle)

The Citric Acid Cycle (Krebs cycle) involves several organic acids with different carbon numbers. The key acids with 4, 5, and 6 carbons are:

Succinic acid (4C) - A 4-carbon intermediate formed after the decarboxylation of α-Ketoglutaric acid.

α-Ketoglutaric acid (5C) - A 5-carbon compound that undergoes oxidative decarboxylation to form Succinyl-CoA.

Citric acid (6C) - The 6-carbon compound formed initially by the condensation of oxaloacetate and acetyl-CoA.

Thus, the correct answer is (D) Succinic acid, α-Ketoglutaric acid and Citric acid, as these represent the 4C, 5C, and 6C acids respectively in the Citric Acid Cycle.

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Concepts Used:

Aerobic respiration

It is the release of a relatively large amount of energy in cells by the breakdown of food substances in the presence of oxygen

Glucose + Oxygen → Carbon Dioxide + Water.