Question:

DNA replication is semi-conservative because ......

Updated On: Dec 3, 2024
  • Only one of the parent strands acts as template
  • Both the strands of the new molecule are synthesised de novo
  • One of the strands in each molecule synthesised is parental and the other new
  • The daughter strands synthesised are dispersive
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The Correct Option is C

Solution and Explanation

Semi conservative replication of DNA was proved by work of Meselson and Stahl (1958). They grew E.coli for many generations in medium with N till the bacterial DNA became completely labelled with N. Then they transferred it to N containing medium and first generation showed DNA with both N and N in equal amount. It proved semi conservative nature of replication i.e., the two resulting double strands are identical, and each of them consists of one original and one newly synthesized strand.
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Concepts Used:

The Molecular Basis of Inheritance

DNA Replication:

DNA synthesis is commenced at particular points within the DNA strand referred to as ‘origins’, which are certain coding regions. There are numerous origin sites, and when replication of DNA starts, these sites are mentioned as replication forks. Within the replication, the complex is the enzyme DNA Helicase, so that they can be utilized as a template for replication. DNA Primase is another enzyme that's essential in DNA replication.

RNA:

Ribonucleic acid (RNA) is an essential biological macromolecule that exists all together in biological cells. It is principally involved in the synthesis of proteins, that carry the messenger instructions from DNA, which itself contains the genetic instructions needed for the event and maintenance of life. In some viruses, RNA, in spite of DNA, carries genetic information.

Genetic Code:

Genetic code is the term we use in the manner that the four bases of DNA--the A, C, G, and Ts--are strung together in a way that the ribosome, the cellular machinery, can read them and switch them into a protein. In the ordering, every three nucleotides during a row count as a triplet and code for one amino alkanoic acid.

Read More: Molecular Basis of Inheritance