Question

_______ defined as "an immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions."

• A. \( \text{Hypersensitivity} \)
• B. \( \text{Supersensitivity} \)
• C. \( \text{Intolerance} \)
• D. \( \text{Idiosyncrasy} \)

Hint:

Remember "immuno" for hypersensitivity (drug allergy). It's an immune system response, unlike other adverse drug reactions.

Answer 1

The Correct Option is A

Hypersensitivity (or a drug allergy) is defined as an adverse reaction to a drug that results from a previous exposure and involves an immunological mechanism. The symptoms are often stereotyped and are not directly related to the drug's normal pharmacological effects. Supersensitivity refers to an increased responsiveness of a target cell to a drug after chronic exposure to an antagonist. Intolerance describes a lower-than-expected threshold to the normal pharmacological effect of a drug. Idiosyncrasy is an unusual or unexpected reaction to a drug that is not immunologically mediated or predictable.