Question

Cowden syndrome

• A. P53
• B. PTEN
• C. Rb
• D. Ras

Answer 1

The Correct Option is B

Cowden syndrome is an autosomal dominant genetic disorder characterized by multiple benign hamartomas and an increased risk of certain malignancies. The condition is closely linked to mutations in the PTEN gene, which is a tumor suppressor gene that negatively regulates intracellular signaling pathways. When PTEN is mutated, these pathways may become overactive, leading to uncontrolled cell growth and tumor formation associated with Cowden syndrome.