Question:

Conversion of Norepinephrine to epinephrine is mainly by?

Updated On: Jul 14, 2025
  • S-adenosyl methionine
  • Arginine
  • Phenylalanine
  • Dehydrogenease
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The Correct Option is A

Solution and Explanation

Conversion of norepinephrine to epinephrine is a biochemical process that occurs in the adrenal medulla. The enzyme responsible for this conversion is phenylethanolamine N-methyltransferase (PNMT). The conversion involves the transfer of a methyl group to norepinephrine to form epinephrine. This process requires a methyl donor, which is S-adenosyl methionine (SAM). SAM donates a methyl group to norepinephrine, facilitating its conversion to epinephrine. Thus, the correct option for the conversion of norepinephrine to epinephrine is S-adenosyl methionine.
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