Question

Commonly, which reaction on histones leads to the silencing of genes?

• A. \( \text{Phosphorylation} \)
• B. \( \text{Methylation} \)
• C. \( \text{Acetylation} \)
• D. \( \text{Demethylation} \)

Hint:

Epigenetic modifications, like histone methylation, influence gene expression without altering DNA sequences.

Answer 1

The Correct Option is B

Histone methylation is a key mechanism in gene silencing, modifying chromatin structure to restrict transcription factor access. It typically occurs on lysine residues in histone tails, leading to chromatin compaction and decreased gene expression. In contrast, acetylation promotes transcription by loosening chromatin, allowing gene activation.