Question

Cilostazol, a drug used in the treatment of intermittent claudication, inhibits which phosphodiesterase enzyme for its clinical effect?

• A. \( \text{PDE3} \)
• B. \( \text{PDE4} \)
• C. \( \text{PDE5} \)
• D. \( \text{PDE6} \)

Hint:

PDE3 inhibitors enhance vasodilation, making them beneficial in conditions with arterial occlusion and poor circulation.

Answer 1

The Correct Option is A

Cilostazol is a phosphodiesterase-3 (PDE3) inhibitor, used to treat intermittent claudication. By inhibiting PDE3, it increases intracellular cyclic AMP (cAMP) levels, leading to vasodilation and platelet inhibition. This effect improves blood flow to the extremities and reduces clotting risk.