Bt (Bacillus thuringiensis) toxin is a crystal protein (Cry protein) that targets the midgut epithelial cells of susceptible insects, particularly Lepidopteran larvae. The toxin binds to receptors on the epithelial cells, forms pores, disrupts osmotic balance, causes cell swelling and lysis, ultimately killing the insect. Bt toxin does not inhibit protein synthesis or generate heat; its primary mode is physical disruption of gut cells.