Question

Bicuculline acts as:

• A. \( \text{Antagonist of GABAA} \)
• B. \( \text{Agonist of GABAA} \)
• C. \( \text{Agonist of nicotinic receptors} \)
• D. \( \text{Agonist of NMDA receptor} \)

Hint:

GABA antagonists decrease inhibition in neural circuits, which can be applied in studying excitatory neurological disorders.

Answer 1

The Correct Option is A

Bicuculline is a GABA\(_A\) antagonist, meaning it inhibits the action of GABA (gamma-aminobutyric acid). It induces neuronal excitation by preventing inhibitory neurotransmission, often used in neuropharmacological studies. This antagonism can lead to convulsions, making bicuculline useful for epilepsy research.