Question

Apoptotic gene is:

• A. Bax
• B. Bcl2
• C. Bclx
• D. Mcl

Answer 1

The Correct Option is B

The question relates to identifying apoptotic genes, which are involved in the process of apoptosis, a form of programmed cell death that is crucial in development and homeostasis. The options provided are genes that belong to the Bcl-2 family. This family contains both pro-apoptotic and anti-apoptotic members, playing key roles in regulating apoptosis.

Let's analyze the options:

• Bax: Pro-apoptotic gene, promotes apoptosis.
• Bcl2: Anti-apoptotic gene, inhibits apoptosis.
• Bclx: Includes pro-apoptotic (Bcl-xS) and anti-apoptotic (Bcl-xL) isoforms.
• Mcl: Typically refers to Mcl-1, an anti-apoptotic member of the Bcl-2 family.

Among these genes, Bcl2 is well-known for its anti-apoptotic function. It helps in cell survival by preventing them from undergoing apoptosis, making it an important factor in the balance between cell death and survival. Nevertheless, in the context of the question, the term "apoptotic gene" typically denotes genes involved in the regulation of apoptosis, whether promoting or inhibiting it.

Considering the function of the genes and the context of the options provided, Bcl2 may be interpreted as the correct answer, though it's main role is inhibitory, its general categorization still falls within apoptosis-related genes.