Question

Although Hemophilia and sickle cell anemia are two blood-related Mendelian disorders, yet they differ in their pattern of inheritance. State any two differences.

Answer 1

The two differences in inheritance patterns between Hemophilia and Sickle Cell Anemia are:
1. Hemophilia is X-linked recessive, meaning it is carried on the X chromosome and primarily affects males, while Sickle Cell Anemia is autosomal recessive, meaning it is inherited through non-sex chromosomes.
2. In Hemophilia, a single X chromosome carrying the defective gene is enough to express the disorder in males, but in Sickle Cell Anemia, both alleles must be defective (homozygous) for the disorder to be expressed in an individual.