Question

Alogliptin, saxagliptin, and vildagliptin share a structural feature responsible for reaction with DPP-4. What is that?

• A. \( \text{Nitrilo group} \)
• B. \( \beta\text{-aminoacid group} \)
• C. \( \text{Adamantane ring} \)
• D. \( \text{Pyrrolidine} \)

Hint:

The nitrilo group enhances selectivity in DPP-4 inhibition, aiding in diabetes management.

Answer 1

The Correct Option is A

DPP-4 inhibitors, including alogliptin, saxagliptin, and vildagliptin, contain a nitrilo (-CN) group, crucial for enzyme inhibition. This structural motif enhances DPP-4 binding affinity, prolonging GLP-1 activity to improve glycemic control in diabetes. Other groups listed have different pharmacological roles.