Question

All of the following are first line antitubercular drugs except

• A. Isoniazid
• B. Rifampicin
• C. Kanamycin
• D. Ethambutol

Hint:

The first-line antitubercular drugs include Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide. Kanamycin is a second-line drug used for multidrug-resistant tuberculosis.

Answer 1

The Correct Option is C

Step 1: Understanding first-line antitubercular drugs.
First-line antitubercular drugs are the core medications used to treat active tuberculosis. These include a combination of drugs that work synergistically to kill the Mycobacterium tuberculosis bacteria.
Step 2: Analyzing the options.

• (A) Isoniazid: Correct. Isoniazid is one of the first-line drugs for tuberculosis, used to inhibit the synthesis of mycolic acids in the bacterial cell wall.
• (B) Rifampicin: Correct. Rifampicin is another first-line drug that inhibits bacterial RNA synthesis, and it is essential in the treatment regimen for tuberculosis.
• (C) Kanamycin: Incorrect. Kanamycin is an aminoglycoside used as a second-line drug for multidrug-resistant tuberculosis, not a first-line treatment.
• (D) Ethambutol: Correct. Ethambutol is used as a first-line drug to inhibit the synthesis of the bacterial cell wall.

Step 3: Conclusion.
Kanamycin is not a first-line antitubercular drug, as it is used for resistant strains of tuberculosis and is part of second-line treatment. Final Answer:} Kanamycin.