Question

Neuroleptics mediated parkinsonism is alleviated by

• A. Antimuscarinics
• B. Amantadine
• C. Levodopa
• D. Selegiline

Hint:

In neuroleptic-induced parkinsonism, antimuscarinics are used to balance dopamine and acetylcholine, whereas other drugs like levodopa are more suited for idiopathic Parkinson's disease.

Answer 1

The Correct Option is A

Step 1: Understanding neuroleptic-induced parkinsonism.
Neuroleptic-induced parkinsonism is a side effect of certain antipsychotic drugs, which block dopamine receptors in the brain. This leads to symptoms resembling Parkinson's disease, such as tremors, rigidity, and bradykinesia.
Step 2: Exploring treatment options.
The treatment for neuroleptic-induced parkinsonism primarily focuses on restoring dopamine function or blocking the effects of dopamine antagonism.

• (A) Antimuscarinics: Correct. Antimuscarinic drugs, such as trihexyphenidyl, can help alleviate symptoms by blocking acetylcholine, which balances the dopamine-acetylcholine system in the brain.
• (B) Amantadine: Incorrect. Amantadine is used in treating Parkinson's disease but is less effective for neuroleptic-induced parkinsonism. It works by increasing dopamine release and blocking NMDA receptors.
• (C) Levodopa: Incorrect. Levodopa is used in Parkinson's disease to replenish dopamine, but it is not typically used for neuroleptic-induced parkinsonism.
• (D) Selegiline: Incorrect. Selegiline is a monoamine oxidase B inhibitor used to treat Parkinson's disease, but it is not typically used for neuroleptic-induced parkinsonism.

Step 3: Conclusion.
The most effective treatment for neuroleptic-induced parkinsonism is the use of antimuscarinics, which help restore the balance between dopamine and acetylcholine in the brain. Final Answer:} Antimuscarinics.