Question

Aprepitant, a drug used to prevent late-onset chemotherapy-induced nausea and vomiting, acts through which of the following mechanisms?

• A. NK-1 antagonist
• B. NK-1 agonist
• C. NK-3 antagonist
• D. NK-2 antagonist

Hint:

Aprepitant is an NK-1 antagonist, effective in preventing chemotherapy-induced nausea and vomiting by blocking the action of substance P.

Answer 1

The Correct Option is A

Aprepitant is a medication used to prevent nausea and vomiting caused by chemotherapy. It achieves this by targeting specific receptors in the body that play a role in these symptoms.

The mechanism of action for Aprepitant involves its role as an NK-1 antagonist. The NK-1 (Neurokinin-1) receptor is associated with the emetic (vomiting) reflex. By acting as an antagonist at these receptors, Aprepitant can effectively block the action of substance P, a neurotransmitter that binds to NK-1 receptors and induces nausea and vomiting.

The options provided for the mechanism of action were:

• NK-1 antagonist
• NK-1 agonist
• NK-3 antagonist
• NK-2 antagonist

Considering the pharmacological action of Aprepitant, the correct choice is NK-1 antagonist.