Question

Acute decrease in response to a drug after initial or repeated intake is known as which of the following drug interactions?

• A. \( \text{Additive} \)
• B. \( \text{Permissive} \)
• C. \( \text{Synergetic} \)
• D. \( \text{Tachyphylaxis} \)

Hint:

Tachyphylaxis often necessitates drug-free intervals to maintain therapeutic efficacy in patients.

Answer 1

The Correct Option is D

Tachyphylaxis refers to a rapid decrease in drug response following repeated administration. It is distinct from tolerance, which develops gradually over time. Mechanisms include receptor desensitization or depletion of neurotransmitter stores, common in drugs like nitrates and ephedrine.