Question:

A patient with mediastinal mass was diagnosed with red cell aplasia. What is the probable cause?

Updated On: Jul 16, 2025
  • Bronchogenic carcinoma
  • NHL
  • Thymic neoplasia
  • T cell ALL
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The Correct Option is C

Solution and Explanation

The presence of a mediastinal mass in conjunction with red cell aplasia suggests clinical correlation with a condition known as pure red cell aplasia. This condition often occurs due to the presence of a thymoma, a type of tumor associated with thymic neoplasia. Thymomas are commonly located in the anterior mediastinum, which aligns with the symptoms of a mediastinal mass in the patient.
ConditionAssociation
Thymic neoplasia (Thymoma)Pure red cell aplasia
Bronchogenic carcinomaNot typically associated with red cell aplasia
NHL (Non-Hodgkin Lymphoma)Not typically associated with red cell aplasia
T cell ALL (Acute Lymphoblastic Leukemia)Not typically associated with red cell aplasia
Thus, in a patient diagnosed with red cell aplasia and presenting with a mediastinal mass, thymic neoplasia is the most probable cause. Thymomas can disrupt normal erythropoiesis leading to the observed aplasia.
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