Question

(a) Name the source from which insulin was extracted in earlier times. Why is this insulin no more in use by the diabetic patients?
Answer:
Source: Pancreas of pigs and cows. Reason: Animal insulin caused allergic reactions in some patients due to structural differences from human insulin. (b) Why does the insulin synthesized in the human body undergo processing whereas the insulin produced by Eli Lilly company does not need to undergo any processing? Explain.

Hint:

Recombinant DNA technology allows the production of human insulin, minimizing allergic reactions.

Answer 1

Source: Pancreas of pigs and cows. Reason: Animal insulin caused allergic reactions in some patients due to structural differences from human insulin. (b) Why does the insulin synthesized in the human body undergo processing whereas the insulin produced by Eli Lilly company does not need to undergo any processing? Explain.
% Solution Solution: Human insulin is produced as proinsulin and requires processing to remove Cpeptide. Eli Lilly produces readytouse recombinant insulin without requiring further processing.