Inflammation is the defence reaction of tissue to injury, infection, or irritation by chemicals or physical agents. Cells in the affected tissue release various substances, including histamine, serotonin, kinins, and prostaglandins. These cause localized dilation of blood vessels so that fluid leaks out and blood flow is increased. They also attract white blood cells (lymphocytes) to the site. Overall, these responses lead to swelling, redness, heat, and often pain. White blood cells, particularly phagocytes, enter the tissue and an immune response is stimulated. A gradual healing process usually follows.