Question

A 40 year old person presented with 10*8 swelling in a retroperitoneal, biopsy from the lesion is as shown below. Molecular analysis demonstrated t(12,16). A most probable diagnosis is

• A. Myxoid liposarcoma
• B. Lipoma
• C. Synovial sarcoma
• D. Pleomorphic sarcoma

Answer 1

The Correct Option is A

The question involves determining the most probable diagnosis given specific medical details. The patient is a 40-year-old with a 10*8 swelling in the retroperitoneal area, and molecular analysis shows a chromosomal translocation of t(12;16). Now, let's analyze the information and arrive at the diagnosis.

1. Understanding the t(12;16) Translocation:
   • In oncogenesis, specific chromosomal translocations can be indicative of certain tumors.
   • The translocation t(12;16) is characteristic of myxoid liposarcoma.
2. Associating Details with Possible Diagnoses:
   • Myxoid Liposarcoma: Often involves the t(12;16) chromosomal translocation.
   • Lipoma: Generally benign and not associated with specific translocations.
   • Synovial Sarcoma: Usually involves translocation t(X;18).
   • Pleomorphic Sarcoma: Lacks specific translocations like t(12;16).
3. Conclusion:
   • The presence of the t(12;16) translocation uniquely supports the diagnosis of Myxoid Liposarcoma.

Thus, based on molecular analysis and the characteristics of the options, the most probable diagnosis for the patient is Myxoid Liposarcoma.