Step 1: Background.
Mendel published his work on pea plant experiments in 1865, but it remained unnoticed until 1900, when rediscovered independently by De Vries, Correns, and Tschermak.
Step 2: Reasons for unrecognition. \begin{enumerate} \item Ahead of time: Mendel's work was conceptually advanced, and the scientific community of his time could not appreciate the significance of statistical analysis and probability in biology. \item Lack of knowledge of chromosomes: Cytological studies of chromosomes and their role in heredity were not understood then, so Mendel's "factors" (genes) could not be correlated with physical structures. \end{enumerate}
Step 3: Conclusion.
Only after cytology and genetics advanced, Mendel's laws were recognized as the foundation of heredity.
1. Perform a cross between two sickle cell carriers. What ratio is obtained between carrier, disease free and diseased individuals in F1 progeny? Name the nitrogenous base substituted, in the haemoglobin molecule in this disease.
2. Explain the difference in inheritance pattern of flower colour in garden pea plant and snap-dragon plant with the help of monohybrid crosses.
OR,
Explain with the help of well-labelled diagrams how lac operon operates in E. coli :
1. In presence of an inducer.
2. In absence of an inducer.
Study the pedigree chart given below, showing the inheritance pattern of blood group in a family:

Answer the following questions:
(a) Give the possible genotypes of individual 1 and 2.
(b) Which antigen or antigens will be present on the plasma membranes of the R.B.Cs of individuals ‘5’ and ‘8’?
The sequence of nitrogenous bases in a segment of a coding strand of DNA is
5' – AATGCTAGGCAC – 3'. Choose the option that shows the correct sequence of nitrogenous bases in the mRNA transcribed by the DNA.