Question

Which one of the following tissues/organs is least likely to experience graft rejection when transplanted from a person to an unrelated person?

• A. ( Bone marrow )
• B. ( Cornea )
• C. ( Heart )
• D. ( Kidney )

Hint:

When considering transplantation, the immunological aspects of the graft, such as blood supply and lymphatic drainage, play crucial roles in the likelihood of rejection. Understanding these factors can aid in better management and treatment approaches.

Answer 1

The Correct Option is B

Among the listed options, the cornea is known to exhibit the lowest incidence of graft rejection. 
Analysis of Each Option: (A) Bone marrow: Highly sensitive to compatibility issues and requires close matching of HLA types due to its role in the immune system. 
(B) Cornea: Correct. The cornea is avascular (lacks blood vessels), which significantly reduces the risk of immune rejection. This avascularity prevents the direct access of immune cells to the transplanted tissue, making it an ideal graft that is less likely to be rejected. 
(C) Heart: The heart is highly vascular and highly susceptible to immune-mediated rejection, requiring immunosuppressive therapy post-transplantation. 
(D) Kidney: Like the heart, the kidney is also highly vascular and prone to rejection, necessitating careful matching and immunosuppression. Conclusion:
Explanation: The cornea's lack of direct blood supply is the primary reason it is less susceptible to the immune reactions typically seen in other transplanted organs or tissues. This unique characteristic allows it to be the safest and most successful allograft with the lowest chance of rejection.