Question

Which one of the following is required for the development of B-cells in the bone marrow?

• A. Stromal cells
• B. Dendritic cells
• C. Kupffer cells
• D. NK cells

Hint:

Stromal cells in the bone marrow provide necessary signals and the microenvironment required for the development of B-cells.

Answer 1

The Correct Option is A

Let's analyze each option:
(1) Stromal cells: Stromal cells are essential for the development of B-cells in the bone marrow. They provide signals and structural support necessary for B-cell maturation. This is the correct answer.
(2) Dendritic cells: Dendritic cells are involved in antigen presentation and immune activation, but they do not play a role in B-cell development in the bone marrow. Hence, this is not the correct answer.
(3) Kupffer cells: Kupffer cells are specialized macrophages in the liver and do not participate in the development of B-cells in the bone marrow. Hence, this is not the correct answer.
(4) NK cells: NK cells play a role in immune surveillance but are not involved in the development of B-cells in the bone marrow. Hence, this is not the correct answer.
Conclusion: The correct answer is Option 1: Stromal cells as they are required for the development and maturation of B-cells in the bone marrow.