The gradually increasing contraction of ventricular muscles during systole first causes the closure of bicuspid and tricuspid valves (AV valves), producing a lowpitched "lubb" sound. Later, it causes the opening of the semilunar valves of systemic and pulmonary aorta. At the end of ventricular systole, semilunar valves shut, producing the second, louder heart sound, the "dup". Thus each heart beat is accompanied by a "lubb-dup" sound.