Question

Which one of the following hormones transmit their signal via nuclear receptors?

• A. Thyroid hormone
• B. Follicle Stimulating hormone
• C. Insulin
• D. Luteinizing hormone

Hint:

Nuclear receptors typically respond to lipophilic hormones like thyroid hormones, steroid hormones, and retinoids, allowing them to regulate gene expression directly within the nucleus.

Answer 1

The Correct Option is A

Step 1: Understand the concept of nuclear receptors.
Nuclear receptors are intracellular receptors that bind to lipid-soluble hormones (such as steroid and thyroid hormones). Once bound, these receptors act as transcription factors, regulating gene expression by interacting with DNA in the nucleus.

Step 2: Evaluate the hormones.

• Thyroid hormone: ✅ Correct. Lipophilic, crosses the cell membrane, binds to nuclear receptors, and regulates gene expression.
• Follicle Stimulating Hormone (FSH): ❌ Water-soluble, acts via membrane-bound receptors and second messenger systems.
• Insulin: ❌ Peptide hormone, acts through a tyrosine kinase receptor on the cell surface, not nuclear receptors.
• Luteinizing Hormone (LH): ❌ Like FSH, it is water-soluble and works via membrane receptors and G-protein coupled pathways.

Step 3: Conclusion.
The hormone that transmits its signal via nuclear receptors is Thyroid hormone.

Correct Answer: Option (1)