Question

Which of the following would be most affected in a cell lacking functional phosphatidylinositol-4,5-bisphosphate (PIP2)?

• A. Activation of protein kinase A
• B. Activation of phospholipase C
• C. DNA replication
• D. Protein synthesis

Hint:

Remember that PIP2 is essential for activating phospholipase C, which is key in many signal transduction pathways.

Answer 1

The Correct Option is B

PIP2 is a key molecule involved in the activation of phospholipase C (PLC), which in turn generates secondary messengers like inositol trisphosphate (IP3) and diacylglycerol (DAG). These messengers are involved in a variety of cellular signaling processes. Without functional PIP2, PLC activation would be severely impaired.