Step 1: Understanding the LAPS structure.
The LAPS with EIS structure involves a semiconductor covered with an insulator layer (SiO2), and a sensing layer is deposited on the insulator.
Step 2: Enzyme in LAPS.
LAPS does not use enzymes for observing spatial distribution of substrates. This part of the statement is incorrect, as it misrepresents the functionality of LAPS.
Final Answer:
\[
\boxed{\text{(2)}}
\]