Question

Which of the following reactions is/are catalyzed by aldolase?

• A. Dihydroxyacetone phosphate + Glyceraldehyde-3-phosphate \(\rightarrow\) Fructose 1,6-bisphosphate
• B. Dihydroxyacetone phosphate + Erythrose-4-phosphate \(\rightarrow\) Sedoheptulose-1,7-bisphosphate
• C. Dihydroxyacetone phosphate \(\rightarrow\) Glyceraldehyde-3-phosphate
• D. Glyceraldehyde-3-phosphate + Erythrose-4-phosphate \(\rightarrow\) Sedoheptulose-1,7-bisphosphate

Hint:

Aldolase catalyzes important reactions in both glycolysis and the pentose phosphate pathway, playing a key role in the synthesis of sugar phosphates.

Answer 1

The Correct Option is A, B

Aldolase catalyzes aldol condensation reactions, which involve the condensation of two carbonyl compounds. Let's analyze each option: 
- Option (A): The reaction of Dihydroxyacetone phosphate and Glyceraldehyde-3-phosphate to form Fructose 1,6-bisphosphate is a key step in glycolysis. This reaction is indeed catalyzed by aldolase. Therefore, Option (A) is correct.
- Option (B): The reaction of Dihydroxyacetone phosphate and Erythrose-4-phosphate to form Sedoheptulose-1,7-bisphosphate is part of the pentose phosphate pathway and is also catalyzed by aldolase. Therefore, Option (B) is correct.
- Option (C): The reaction of Dihydroxyacetone phosphate directly converting to Glyceraldehyde-3-phosphate does not involve aldolase. Therefore, Option (C) is incorrect.
- Option (D): The reaction of Glyceraldehyde-3-phosphate and Erythrose-4-phosphate to form Sedoheptulose-1,7-bisphosphate is indeed catalyzed by aldolase in the pentose phosphate pathway. Therefore, Option (D) is incorrect.
Thus, the correct answer is (A), (B).