Question

Which of the following metabolite(s) accumulate(s) in the blood of a human adult consuming a ketogenic diet?

• A. D-β-hydroxybutyrate
• B. Acetoacetate
• C. Pyruvate
• D. Oxaloacetate

Hint:

A ketogenic diet increases the production of ketone bodies like D-β-hydroxybutyrate and acetoacetate, which provide an alternative energy source to glucose.

Answer 1

The Correct Option is A, B

Step 1: Understanding the metabolic effects of a ketogenic diet.
A ketogenic diet promotes the production of ketone bodies from fatty acids. These ketone bodies are used as an alternative energy source when glucose is limited.
Step 2: Analyzing the options.
- (A) Correct: D-β-hydroxybutyrate is one of the primary ketone bodies produced during ketosis, and its levels accumulate in the blood during a ketogenic diet.
- (B) Correct: Acetoacetate is another ketone body that accumulates in the blood during a ketogenic diet, serving as a source of energy for tissues like the brain.
- (C) Incorrect: Pyruvate is a key intermediate in glucose metabolism but does not accumulate during a ketogenic diet. In fact, its production is reduced in favor of ketone bodies.
- (D) Incorrect: Oxaloacetate is involved in gluconeogenesis and is not a product of ketogenesis. Its levels are typically low during a ketogenic diet.
Final Answer: \[ \boxed{\text{(A) and (B) are correct.}} \]