Question

Which of the following medications is most commonly linked to the occurrence of fibrous gingival enlargement?

• A. Nifedipine
• B. Acetaminophen
• C. Amoxicillin
• D. Tranexamic acid

Hint:

Remember the “3 P’s” of drug-induced gingival enlargement: Phenytoin, Procardia (nifedipine), and Prograf (cyclosporine).

Answer 1

The Correct Option is A

Step 1: Understanding Drug-Induced Gingival Enlargement.
Drug-induced gingival enlargement is a well-recognized adverse effect characterized by fibrous overgrowth of gingival tissuesIt is commonly associated with certain classes of medications
Step 2: Common Drugs Causing Gingival Enlargement.
The three major groups known to cause gingival enlargement are:
Anticonvulsants (e.g., phenytoin)
Calcium channel blockers (e.g., nifedipine, amlodipine)
Immunosuppressants (e.g., cyclosporine)
Among these, nifedipine, a calcium channel blocker used for hypertension and angina, is frequently implicated
Step 3: Evaluation of Options.
(A) Nifedipine: CorrectA calcium channel blocker strongly associated with fibrous gingival enlargement
(B) Acetaminophen: An analgesic and antipyretic not associated with gingival overgrowth
(C) Amoxicillin: An antibiotic not linked to fibrous gingival enlargement
(D) Tranexamic acid: An antifibrinolytic agent not known to cause gingival overgrowth
Step 4: Conclusion.
Therefore, nifedipine is the medication most commonly linked to fibrous gingival enlargement