Question

Cri du chat syndrome is associated with a deletion on which part of a chromosome?

• A. Chromosome 5q arm
• B. Chromosome 15p arm
• C. Chromosome 15q arm
• D. Chromosome 5p arm

Hint:

Cri du chat = 5p deletion = Short arm of chromosome 5.

Answer 1

The Correct Option is D

Step 1: Understanding Cri du chat Syndrome.
Cri du chat syndrome is a genetic disorder characterized by a high-pitched cat-like cry in infants, microcephaly, intellectual disability, and facial abnormalitiesThe name "Cri du chat" means "cry of the cat" in French
Step 2: Chromosomal Basis.
This syndrome occurs due to a deletion of the short arm (p arm) of chromosome 5It is commonly referred to as 5p deletion syndrome
Step 3: Analysis of Options.
(A) Chromosome 5q arm — Incorrect because deletion occurs on the short arm (p), not long arm (q)
(B) Chromosome 15p arm — Not associated with Cri du chat syndrome
(C) Chromosome 15q arm — Associated with other syndromes such as Prader-Willi or Angelman syndrome
(D) Chromosome 5p arm — Correct deletion site in Cri du chat syndrome
Step 4: Conclusion.
Therefore, Cri du chat syndrome is caused by deletion of the short arm of chromosome 5