Question

Which of the following is true about PAN ?

• A. Microscopy shows fibrinoid necrosis in large arteries
• B. ANCA is positive
• C. 30% of people have HbsAg positive
• D. Patient have hypogammaglobulinemia

Answer 1

The Correct Option is C

PAN, or Polyarteritis Nodosa, is a systemic vasculitis affecting medium and small-sized arteries. It is characterized by transmural inflammation and fibrinoid necrosis of the arterial wall.

Key characteristics include:

• The presence of fibrinoid necrosis in the affected arteries, typically medium-sized arteries, rather than large ones.
• Antineutrophil cytoplasmic antibodies (ANCA) are generally negative in PAN, as opposed to some other forms of vasculitis.
• A notable association is that approximately 30% of PAN cases are linked to Hepatitis B virus infection, with Hepatitis B surface antigen (HbsAg) being positive in about 30% of cases.
• Hypogammaglobulinemia is not a typical finding in PAN.

Therefore, the correct statement regarding PAN is: 30% of people have HbsAg positive.