Question:

Which of the following is NOT a role of histamine?

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Histamine plays a key role in stimulating the release of gastric acid and pepsin, but does not neutralize acid.
Updated On: Feb 4, 2026
  • To neutralize excess of acid in stomach
  • To contract smooth muscles of blood vessels of stomach wall
  • To stimulate the secretion of pepsin
  • To stimulate the secretion of hydrochloric acid
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The Correct Option is A

Solution and Explanation

Step 1: Understanding the role of histamine.
Histamine is a chemical involved in several functions, such as the immune response and regulating the stomach’s secretion of acid. It stimulates the secretion of gastric acid and pepsin in the stomach, and causes the contraction of smooth muscles of blood vessels. It does not neutralize acid.
Step 2: Analyzing the options.
(A) To neutralize excess of acid in stomach: Correct — This is NOT a role of histamine. Histamine does not neutralize acid, but instead promotes the secretion of acid in the stomach.
(B) To contract smooth muscles of blood vessels of stomach wall: Incorrect. Histamine does cause the contraction of smooth muscles in the stomach wall and blood vessels.
(C) To stimulate the secretion of pepsin: Incorrect. Histamine stimulates the secretion of pepsin, which is involved in the digestion of proteins in the stomach.
(D) To stimulate the secretion of hydrochloric acid: Incorrect. Histamine is involved in stimulating the secretion of hydrochloric acid in the stomach, which aids in digestion.
Step 3: Conclusion.
The correct answer is (A) To neutralize excess of acid in stomach, as histamine is involved in acid secretion, not neutralization.
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