Question

Which of the following is/are responsible for reversible receptor–ligand interaction?

• A. Ionic interactions
• B. Hydrogen bonding
• C. Peptide bonding
• D. Hydrophobic interactions

Hint:

Reversible receptor-ligand interactions are primarily non-covalent, involving ionic, hydrogen, and hydrophobic interactions.

Answer 1

The Correct Option is A, B, D

Step 1: Understanding reversible receptor-ligand interactions.
Reversible interactions between receptors and ligands are typically mediated by non-covalent bonds such as ionic interactions, hydrogen bonding, and hydrophobic interactions. These interactions allow for the binding and release of ligands.

Step 2: Analyzing the options.
- (A) Correct, ionic interactions are crucial for reversible receptor-ligand binding as they involve electrostatic attraction between charged groups.
- (B) Correct, hydrogen bonds also play a significant role in receptor-ligand interactions by providing reversible attractions between molecules.
- (C) Incorrect, peptide bonding is a covalent bond and not typically involved in reversible interactions.
- (D) Correct, hydrophobic interactions help stabilize the binding between receptors and ligands, particularly in non-polar environments.
Step 3: Conclusion.
Thus, the correct answer is (A), (B), and (D) Ionic interactions, Hydrogen bonding, and Hydrophobic interactions.