Question

Which of the following is a humanized antibody?

• A. Doxorubicin
• B. Sulforaphane
• C. Vimentin
• D. Herceptin

Answer 1

The Correct Option is D

A humanized antibody is a monoclonal antibody (mAb) that has been genetically engineered to reduce its immunogenicity in humans by replacing most of its non-human regions with human antibody sequences. 

Step 1: Understanding Humanized Antibodies - Monoclonal antibodies (mAbs) are designed to target specific proteins in the body, commonly used in cancer therapy and autoimmune diseases. - Humanized antibodies are developed to minimize immune rejection while retaining the ability to bind to target antigens. 

Step 2: Evaluating the Options - Option (A) - Incorrect: Doxorubicin is a chemotherapeutic agent (anthracycline), not an antibody. - Option (B) - Incorrect: Sulforaphane is a phytochemical found in cruciferous vegetables with anti-cancer properties. - Option (C) - Incorrect: Vimentin is a cytoskeletal protein, not an antibody. - Option (D) - Correct: Herceptin (Trastuzumab) is a humanized monoclonal antibody that targets the HER2 receptor in breast cancer therapy. 

Step 3: Conclusion Since Herceptin is a humanized monoclonal antibody used in cancer treatment, the correct answer is option (D).