An operator \( \hat{O} \) is Hermitian if:
\[
\langle \psi | \hat{O} \phi \rangle = \langle \hat{O} \psi | \phi \rangle
\]
For differential operators:
\[
\left(\frac{d}{dx}\right)^\dagger = -\frac{d}{dx}
\]
which is not Hermitian.
\[
\left(\frac{d^2}{dx^2}\right)^\dagger = \frac{d^2}{dx^2}
\]
is not negative definite, so it's not Hermitian.
\[
\left(-\frac{d^2}{dx^2}\right)^\dagger = -\frac{d^2}{dx^2}
\]
which satisfies the Hermitian condition.