Question

Which of the following enzymes is directly inhibited by statins to reduce cholesterol biosynthesis in the liver?

• A. Lipase
• B. HMG-CoA reductase
• C. Amylase
• D. Pepsin

Hint:

HMG-CoA reductase is the rate-limiting enzyme in the cholesterol synthesis pathway. Statins block this enzyme, reducing LDL levels significantly.

Answer 1

The Correct Option is B

Statins exert their cholesterol-lowering effect by inhibiting the enzyme HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase). This enzyme catalyzes an early and rate-limiting step in the biosynthesis of cholesterol in the liver. By inhibiting this enzyme, statins decrease the intracellular synthesis of cholesterol, which in turn upregulates LDL receptors and increases LDL clearance from the bloodstream. Option (a) Lipase breaks down lipids but is not involved in cholesterol biosynthesis.
Option (c) Amylase helps digest carbohydrates.
Option (d) Pepsin breaks down proteins in the stomach.
Only option (b) is linked to cholesterol synthesis, making it the correct answer.