Question

Which of the following enzyme is inhibited by citrate in Kreb's cycle?

• A. Phospho-fructo kinase II (PFKII)
• B. Aldolase
• C. Pyruvate kinase
• D. Phosphoglycerate mutase (PGM)

Hint:

Remember that citrate plays a role in feedback inhibition to regulate energy production efficiently.

Answer 1

The Correct Option is A

Citrate, an intermediate in the Kreb's cycle, acts as a feedback inhibitor for Phospho-fructo kinase II (PFKII). This enzyme is a key regulatory point in glycolysis, controlling the rate at which glucose is metabolized. By inhibiting PFKII, citrate helps balance energy production between glycolysis and the Kreb's cycle, ensuring efficient energy use.