Question

Which of the following enzyme activities can be estimated in red blood cells to diagnose vitamin B2 deficiency?

• A. Transketolase
• B. Glutathione reductase
• C. Kynureninase
• D. Pyruvate dehydrogenase

Answer 1

The Correct Option is B

In the context of diagnosing vitamin B2 deficiency, understanding the role of red blood cell enzyme activities is crucial. Vitamin B2, also known as riboflavin, is a vital component of the coenzymes FAD (flavin adenine dinucleotide) and FMN (flavin mononucleotide), which are involved in various biochemical reactions.

Glutathione reductase activity in red blood cells can be used to assess riboflavin status, as this enzyme requires FAD as a cofactor. Reduced glutathione reductase activity indicates a potential riboflavin deficiency. Measuring the activity of this enzyme provides insight into the body's current status of vitamin B2, thereby aiding in the diagnosis of its deficiency.