Question

Which of the following drug is used in SIADH?

• A. Tolvapatan
• B. Desmopressin
• C. Vwb factor
• D. Terlipressin

Answer 1

The Correct Option is A

To solve the question of which drug is used in SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion), we need to understand the condition and the action of the listed drugs. SIADH is characterized by excessive release of antidiuretic hormone (ADH), leading to water retention and hyponatremia. Therefore, treatments often involve drugs that counteract these effects through diuresis.

The correct option here is Tolvapatan. It is a selective vasopressin V2-receptor antagonist, often used to treat hyponatremia (low sodium levels) associated with SIADH. By blocking the action of vasopressin, it prevents water reabsorption in the kidneys, aiding in alleviating water retention.

Other options such as Desmopressin, Vwb factor, and Terlipressin do not serve this primary purpose:

• Desmopressin is a synthetic analog of ADH and would exacerbate SIADH symptoms by promoting water retention.
• Vwb factor is related to clotting mechanisms and has no role in treating SIADH.
• Terlipressin is a vasopressin analog used primarily in bleeding esophageal varices; it would not be suitable for SIADH.