Question:
Which of the following does not have a negative effect on PFK?
Which of the following does not have a negative effect on PFK?
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PFK is activated by AMP and inhibited by ATP and citrate, which helps regulate glycolysis based on the energy status of the cell.
Updated On: Feb 27, 2025
ATP
- Citrate
- pH
- AMP
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The Correct Option is D
Solution and Explanation
- ATP, citrate, and low pH all inhibit phosphofructokinase (PFK), which is a key enzyme in glycolysis. These factors indicate high energy levels or unfavorable conditions for glycolysis.
- AMP, however, stimulates PFK as it indicates low energy levels in the cell, signaling the need for increased glycolysis to produce more ATP.
Conclusion: AMP stimulates PFK activity, so option (d) is the correct answer.
- AMP, however, stimulates PFK as it indicates low energy levels in the cell, signaling the need for increased glycolysis to produce more ATP.
Conclusion: AMP stimulates PFK activity, so option (d) is the correct answer.
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