Question

Which of the following clotting factors is needed for gamma-glutamyl carboxylase?

• A. Factors II, VIII, IX, X
• B. Factors II, VII, IX, and X
• C. Factors II, VII, IX, XI
• D. Factors II, VIII, X, XI

Answer 1

The Correct Option is B

The enzyme gamma-glutamyl carboxylase plays a crucial role in the blood clotting process. It is responsible for converting specific glutamic acid residues in certain clotting factors into gamma-carboxyglutamate. This modification enables these factors to bind calcium ions, which is essential for their activation and function.

The clotting factors that require gamma-carboxylation by gamma-glutamyl carboxylase include:

• Factor II (Prothrombin)
• Factor VII
• Factor IX
• Factor X

Each of these factors contains glutamic acid residues that undergo gamma-carboxylation, which is a vitamin K-dependent process. Vitamin K serves as a cofactor for gamma-glutamyl carboxylase. Consequently, the correct option listing the factors that need gamma-glutamyl carboxylase is Factors II, VII, IX, and X.