Question

Which of the following cells are most shear sensitive?

• A. Mammalian
• B. Plant
• C. Bacteria
• D. Fungi

Hint:

When working with mammalian cells, reduce shear stress during processing to avoid cell damage.

Answer 1

The Correct Option is A

Step 1: Understanding Shear Sensitivity 
Shear sensitivity refers to the ability of cells to withstand mechanical stress without damage. 
Step 2: Evaluating Cell Types 
- Mammalian cells: Sensitive to shear stress, which can damage their membrane and affect viability. 
- Plant cells: Generally more robust, although they can also be affected by shear. 
- Bacteria: More resistant to shear stress compared to mammalian cells. 
- Fungi: Less sensitive to shear stress. 
Step 3: Conclusion 
Mammalian cells are the most shear-sensitive due to their delicate structure.