Question

Which of the following antihypertensive drug is avoided in patients with high serum uric acid levels ?

• A. Hydrochlorothiazide
• B. Enalapril
• C. Prazosin
• D. Atenolol

Answer 1

The Correct Option is A

In pharmacology, selecting the appropriate antihypertensive drug involves considering the patient's comorbid conditions. In cases where patients have elevated serum uric acid levels, such as in gout, certain medications should be avoided due to their side effects. Hydrochlorothiazide, a thiazide diuretic, is known to increase uric acid levels by reducing its excretion in the kidneys. Therefore, it can exacerbate conditions like gout.

Hence, for patients with high serum uric acid levels, hydrochlorothiazide is contraindicated as it may lead to hyperuricemia. Other antihypertensive agents such as Enalapril, Prazosin, or Atenolol do not have this adverse effect and may be considered safer alternatives in such scenarios.

Option	Effect on Uric Acid
Hydrochlorothiazide	Increases
Enalapril	Neutral
Prazosin	Neutral
Atenolol	Neutral

Correct Answer: Hydrochlorothiazide