Step 1: Observe the series terms.
We are given: \(3,\ 6,\ 18,\ 72,\ ?\)
Step 2: Identify the pattern in multipliers.
\[
\begin{aligned}
3 \times 2 &= 6
6 \times 3 &= 18
18 \times 4 &= 72
\Rightarrow 72 \times 4 &= 288
\end{aligned}
\]
Step 3: Validate the consistent multiplier pattern.
The pattern follows:
\[
\text{×2},\ \text{×3},\ \text{×4},\ \text{×4}
\]
Hence, the missing number is:
\[
\boxed{288}
\]