Question

Which is not a prokinetic agent ?

• A. Dopamine antagonist
• B. 5HT4 agonist
• C. Macrolides
• D. Diphenylmethane

Answer 1

The Correct Option is D

In the context of pharmacology, a prokinetic agent is a type of drug that enhances gastrointestinal motility by increasing the frequency or strength of contractions in the small intestine, but without disrupting their rhythm. Here, we need to determine which among the given options is not a prokinetic agent:

• Dopamine antagonist: These drugs can have prokinetic effects. For instance, certain dopamine antagonists like metoclopramide are known to facilitate gastric emptying and small bowel transit.
• 5HT4 agonist: Agonists of the 5HT4 receptor are considered prokinetic. They enhance gastrointestinal motility and are used in conditions requiring accelerated transit through the gut.
• Macrolides: Some macrolide antibiotics can act as motilin receptor agonists, promoting gastrointestinal motility, and are thus classified as prokinetic agents.
• Diphenylmethane: This is a chemical structure that is primarily associated with agents like bisacodyl, which are used as laxatives rather than prokinetics. They work by irritating the intestinal lining and inducing bowel movements through a different mechanism.

Therefore, Diphenylmethane is not considered a prokinetic agent.