Question:
Which gene is typically inserted into host cells to facilitate monoclonal antibody production using hybridoma technology?
Which gene is typically inserted into host cells to facilitate monoclonal antibody production using hybridoma technology?
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HAT resistance is a key component in the selection of hybridoma cells for monoclonal antibody production.
Updated On: Jun 18, 2025
- IgG heavy chain
- Myc oncogene
- HAT resistance gene
- DHFR gene
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The Correct Option is C
Solution and Explanation
In hybridoma technology, the HAT resistance gene is often inserted into host cells. This gene provides resistance to the HAT (Hypoxanthine-Aminopterin-Thymidine) selection medium, allowing only the successfully transfected cells to survive and proliferate, facilitating the production of monoclonal antibodies.
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